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Article

Association of SGK1 gene polymorphisms with type 2 diabetes.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology - 1 Jan 2008

Schwab Matthias, Lupescu Adrian, Mota Maria, Mota Eugen, Frey Andreas, Simon Perikles, Mertens Peter R, Floege Jurgen, Luft Friedrich, Asante-Poku Steven, Schaeffeler Elke, Lang Florian

Abstract excerpt

The serum and glucocorticoid inducible kinase SGK1 is genomically upregulated by glucocorticoids and in turn stimulates a variety of carriers and channels including the renal epithelial Na(+) channel ENaC and the intestinal Na(+) glucose transporter SGLT1. Twin studies disclosed an association of a specific SGK1 haplotype with moderately enhanced blood pressure in individuals who are carrying simultaneously a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18209482
DOI: 10.1159/000113757

Genes

SGK1

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