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Article

Adaptive human CDKAL1 variants underlie hormonal response variations at the enteroinsular axis.

PloS one - 1 Jan 2014

Chang Chia Lin, Cai James J, Huang Shang Yu, Cheng Po Jen, Chueh Ho Yen, Hsu Sheau Yu Teddy

Abstract excerpt

Recent analyses have identified positively selected loci that explain differences in immune responses, body forms, and adaptations to extreme climates, but variants that describe adaptations in energy-balance regulation remain underexplored. To identify variants that confer adaptations in energy-balance regulation, we explored the evolutionary history and functional associations of candidate variants in 207...

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Share to Cyclin-Dependent Kinase 5
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 25222615
DOI: 10.1371/journal.pone.0105410
PMCID: PMC4164438

Genes

CDKAL1
GAD2
GIP
PPARG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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