Molecular evidence for a link between the N363S glucocorticoid receptor polymorphism and altered gene expression.

doi:10.1210/jc.2007-0642

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Article

Molecular evidence for a link between the N363S glucocorticoid receptor polymorphism and altered gene expression.

The Journal of clinical endocrinology and metabolism - 1 Aug 2007

Jewell Christine M, Cidlowski John A

Abstract excerpt

CONTEXT: A single-nucleotide polymorphism (SNP) in the human glucocorticoid receptor (hGR) N363S (rs6195) has been the focus of several clinical studies, and some epidemiological data link this SNP to increased glucocorticoid sensitivity, coronary artery disease, and increased body mass index. However, molecular studies in vitro using reporter gene expression systems have failed, for the most part, to define a...

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Identifiers

PMID: 17535992
DOI: 10.1210/jc.2007-0642
PMCID: PMC2692663

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