Article
Serum- and glucocorticoid-regulated kinase (SGK1) gene and blood pressure.
Hypertension (Dallas, Tex. : 1979) - 1 Sept 2002
Busjahn Andreas, Aydin Atakan, Uhlmann Regina, Krasko Christine, Bähring Sylvia, Szelestei Tamas, Feng Yuxi, Dahm Stephan, Sharma Arya M, Luft Friedrich C, Lang Florian
Abstract excerpt
The serum- and glucose-regulated kinase (SGK1) gene has recently been identified as an important aldosterone-induced protein kinase that mediates trafficking of the renal epithelial Na(+) channel (ENaC) to the cell membrane. Thus, SGK1 is an appealing candidate for blood pressure regulation and possibly essential hypertension. To test this hypothesis, we recruited monozygotic (126 pairs) and dizygotic (70 pairs)...
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