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Article

Gsalpha signalling suppresses PPARgamma2 generation and inhibits 3T3L1 adipogenesis.

The Journal of endocrinology - 1 Aug 2009

Zhang Lei, Paddon Carol, Lewis Mark D, Grennan-Jones Fiona, Ludgate Marian

Abstract excerpt

Since TSH receptor (TSHR) expression increases during adipogenesis and signals via cAMP/phospho-cAMP-response element binding protein (CREB), reported to be necessary and sufficient for adipogenesis, we hypothesised that TSHR activation would induce preadipocyte differentiation. Retroviral vectors introduced constitutively active TSHR (TSHR*) into 3T3L1 preadipocytes; despite increased cAMP (RIA) and phospho-CREB...

Read the complete abstract on PubMed

Topics

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Share to 3T3-L1 Cells
Share to Adipocytes
Share to Adipogenesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclic AMP Response Element-Binding Protein

Share to Forkhead Box Protein O1

Share to GTP-Binding Protein alpha Subunits, Gs

Share to PPAR gamma

Share to Receptors, Thyrotropin

Source

Open in PubMed Open full text

Identifiers

PMID: 19460852
DOI: 10.1677/JOE-09-0099
PMCID: PMC2710974

Genes

TSHR
FOXO1
PPARG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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