Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Thyrotropin receptor activation increases hyaluronan production in preadipocyte fibroblasts: contributory role in hyaluronan accumulation in thyroid dysfunction.

The Journal of biological chemistry - 25 Sept 2009

Zhang Lei, Bowen Timothy, Grennan-Jones Fiona, Paddon Carol, Giles Peter, Webber Jason, Steadman Robert, Ludgate Marian

Abstract excerpt

The thyrotropin receptor (TSHR) is expressed during lineage-specific differentiation (e.g. adipogenesis) and is activated by TSH, thyroid-stimulating antibodies, and gain-of-function mutations (TSHR*). Comparison of gene expression profiles of nonmodified human preadipocytes (n = 4) with the para...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipocytes
Share to Chromatin Immunoprecipitation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enzyme-Linked Immunosorbent Assay

Share to Glucuronosyltransferase

Share to Hyaluronic Acid

Share to Receptors, Thyrotropin

Share to RNA Interference

Share to Thyroid Gland

Source

Open in PubMed Open full text

Identifiers

PMID: 19633293
DOI: 10.1074/jbc.M109.003616
PMCID: PMC2785333

Genes

HAS1
HAS2
TSHR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19633293-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Thyrotropin receptor activation increases hyaluronan production in preadipocyte fibroblasts: contributory role in hyaluronan accumulation in thyroid dysfunction.PMID 19633293Read ↗

Expression of Endogenous Putative TSH Binding Protein in Orbit.Semantic proximity Read ↗

TSH-induced gene expression involves regulation of self-renewal and differentiation-related genes in human bone marrow-derived mesenchymal stem cellsSemantic proximity Read ↗

Pathogenic Phenotype of Adipogenesis and Hyaluronan in Orbital Fibroblasts From Female Graves' Orbitopathy Mouse Model.Semantic proximity Read ↗

A review of TSHR- and IGF-1R-related pathogenesis and treatment of Graves' orbitopathy.Semantic proximity Read ↗

Thyroid Hormone Responsive Genes in Cultured Human FibroblastsSemantic proximity Read ↗

Expression of G(alpha)(s) proteins and TSH receptor signalling in hyperfunctioning thyroid nodules with TSH receptor mutations.Semantic proximity Read ↗

Ablation of TRalpha2 and a concomitant overexpression of alpha1 yields a mixed hypo- and hyperthyroid phenotype in mice.Semantic proximity Read ↗

The Molecular Basis of Thyroid Hormone ActionSemantic proximity Read ↗

Contrasting effects of activating mutations of GalphaS and the thyrotropin receptor on proliferation and differentiation of thyroid follicular cells.Semantic proximity Read ↗

Adipogenesis is differentially impaired by thyroid hormone receptor mutant isoforms.Semantic proximity Read ↗

Physiological Thyroid Hormone Levels Regulate Numerous Skeletal Muscle TranscriptsSemantic proximity Read ↗

Germ Line Mutations in the Thyroid Hormone Receptor Alpha Gene Predispose to Cutaneous Tags and Melanocytic Nevi.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.