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Article

The Pro 12 Ala PPAR gamma gene polymorphism: possible modifier of the activity and severity of thyroid-associated orbitopathy (TAO).

Clinical endocrinology - 1 Mar 2009

Alevizaki Maria, Mantzou Emily, Cimponeriu Adriana, Saltiki Katerina, Philippou George, Wiersinga Wilmar

Abstract excerpt

OBJECTIVE: The PPAR gamma transcription factor, is involved in both adipogenesis and inflammation, which have been implicated in the pathogenesis of thyroid-associated orbitopathy (TAO). The aim of this study was to explore the possibility that the Pro(12)Ala polymorphism of the PPAR gamma gene, associated with a modified transcriptional activity, might be affecting the severity of TAO. SUBJECTS AND DESIGN: We...

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PMID: 18624999
DOI: 10.1111/j.1365-2265.2008.03343.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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