Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Decreased PPAR gamma expression compromises perigonadal-specific fat deposition and insulin sensitivity.

Molecular endocrinology (Baltimore, Md.) - 1 Nov 2009

Tsai Yau-Sheng, Tsai Pei-Jane, Jiang Man-Jin, Chou Ting-Yu, Pendse Avani, Kim Hyung-Suk, Maeda Nobuyo

Abstract excerpt

Mutations and polymorphisms in PPARG have been linked to adiposity and partial lipodystrophy in humans. However, how disturbances in PPARG lead to depot-specific effects on adipose tissue, as shown by the characteristic aberrant fat distribution in patients, remains unclear. By manipulating the 3'-untranslated region of the Pparg gene, we have generated mice with peroxisome proliferator-activated receptor gamma...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipocytes
Share to Body Composition

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enhancer Elements, Genetic

Share to Glucose Tolerance Test

Share to Gonads

Share to Lipid Metabolism

Share to Lipodystrophy

Share to PPAR gamma

Source

Open in PubMed Open full text

Identifiers

PMID: 19749155
DOI: 10.1210/me.2009-0073
PMCID: PMC2775941

Genes

PPARG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Decreased PPAR gamma expression compromises perigonadal-specific fat deposition and insulin sensitivity.PMID 19749155Read ↗

Inguinal Fat Compensates Whole Body Metabolic Functionality in Partially Lipodystrophic Mice with Reduced PPARγ Expression.Semantic proximity Read ↗

Mouse models of PPAR-γ deficiency: dissecting PPAR-γ's role in metabolic homoeostasisSemantic proximity Read ↗

PPARgamma: a critical determinant of body fat distribution in humans and mice.Semantic proximity Read ↗

PPAR gamma as a metabolic regulator: insights from genomics and pharmacology.Semantic proximity Read ↗

PPARgamma in human and mouse physiology.Semantic proximity Read ↗

Muscle-specific PPARgamma-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones.Semantic proximity Read ↗

Leptin Deficiency Unmasks the Deleterious Effects of Impaired Peroxisome Proliferator–Activated Receptor γ Function (P465L PPARγ) in MiceSemantic proximity Read ↗

Peroxisome proliferator-activated receptor-gamma: too much of a good thing causes harm.Semantic proximity Read ↗

Brown vs white adipocytes: The PPARγ coregulator storySemantic proximity Read ↗

Familial partial lipodystrophy resulting from loss-of-function PPARγ pathogenic variants: phenotypic, clinical, and genetic features.Semantic proximity Read ↗

Peroxisome proliferator-activated receptor-gamma and insulin action: insights from human genetics.Semantic proximity Read ↗

A dominant negative peroxisome proliferator-activated receptor-gamma knock-in mouse exhibits features of the metabolic syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.