Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Adipogenesis is differentially impaired by thyroid hormone receptor mutant isoforms.

Journal of molecular endocrinology - 1 Apr 2010

Mishra Alok, Zhu Xu-Guang, Ge Kai, Cheng Sheue-Yann

Abstract excerpt

To understand the roles of thyroid hormone receptors (TRs) in adipogenesis, we adopted a loss-of-function approach. We generated 3T3-L1 cells stably expressing either TRalpha1 mutant (TRalpha1PV) or TRbeta1 mutant (TRbeta1PV). TRalpha1PV and TRbeta1PV are dominant negative mutations with a frames...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3T3-L1 Cells
Share to Adipocytes
Share to Adipogenesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CCAAT-Enhancer-Binding Protein-alpha

Share to Chromatin Immunoprecipitation

Share to PPAR gamma

Share to Receptors, Thyroid Hormone

Share to Triiodothyronine

Source

Open in PubMed Open full text

Identifiers

PMID: 20080985
DOI: 10.1677/JME-09-0137
PMCID: PMC3464097

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20080985-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Adipogenesis is differentially impaired by thyroid hormone receptor mutant isoforms.PMID 20080985Read ↗

Impaired adipogenesis caused by a mutated thyroid hormone alpha1 receptor.Semantic proximity Read ↗

NCoR1 regulates thyroid hormone receptor isoform-dependent adipogenesis.Semantic proximity Read ↗

A dominant negative PPARgamma mutant shows altered cofactor recruitment and inhibits adipogenesis in 3T3-L1 cells.Semantic proximity Read ↗

New insights into regulation of lipid metabolism by thyroid hormone.Semantic proximity Read ↗

Thyroid hormone receptor sumoylation is required for preadipocyte differentiation and proliferation.Semantic proximity Read ↗

Transformer 2β homolog (Drosophila) (TRA2B) regulates protein kinase C δI (PKCδI) splice variant expression during 3T3L1 preadipocyte cell cycle.Semantic proximity Read ↗

A dominant-negative peroxisome proliferator-activated receptor gamma (PPARgamma) mutant is a constitutive repressor and inhibits PPARgamma-mediated adipogenesis.Semantic proximity Read ↗

AGPAT3 deficiency impairs adipocyte differentiation and leads to a lean phenotype in mice.Semantic proximity Read ↗

Characterization of lipid metabolism in insulin-sensitive adipocytes differentiated from immortalized human mesenchymal stem cells.Semantic proximity Read ↗

Isoform-dependent actions of thyroid hormone nuclear receptors: lessons from knockin mutant mice.Semantic proximity Read ↗

The role of the orphan nuclear receptor Rev-Erbα in adipocyte differentiation and functionSemantic proximity Read ↗

PPARs and adipocyte functionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.