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Article

Inhibition of adipogenesis through MAP kinase-mediated phosphorylation of PPARgamma.

Science (New York, N.Y.) - 20 Dec 1996

Hu E, Kim J B, Sarraf P, Spiegelman B M

Abstract excerpt

Adipocyte differentiation is an important component of obesity and other metabolic diseases. This process is strongly inhibited by many mitogens and oncogenes. Several growth factors that inhibit fat cell differentiation caused mitogen-activated protein (MAP) kinase-mediated phosphorylation of th...

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Identifiers

PMID: 8953045
DOI: 10.1126/science.274.5295.2100

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-8953045-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Inhibition of adipogenesis through MAP kinase-mediated phosphorylation of PPARgamma.PMID 8953045Read ↗

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A dominant-negative peroxisome proliferator-activated receptor gamma (PPARgamma) mutant is a constitutive repressor and inhibits PPARgamma-mediated adipogenesis.Semantic proximity Read ↗

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c-Abl tyrosine kinase promotes adipocyte differentiation by targeting PPAR-gamma 2.Semantic proximity Read ↗

Regulation of adipogenesis by a transcriptional repressor that modulates MAPK activation.Semantic proximity Read ↗

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The roles of PPARs in adipocyte differentiationSemantic proximity Read ↗

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