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Article

Expression of Endogenous Putative TSH Binding Protein in Orbit.

Current issues in molecular biology - 27 Oct 2021

Draman Mohd Shazli, Grennan-Jones Fiona, Taylor Peter, Muller Ilaria, Evans Sam, Haridas Anjana, Morris Daniel S, Rees D Aled, Lane Carol, Dayan Colin, Zhang Lei, Ludgate Marian

Abstract excerpt

Thyroid stimulating antibodies (TSAB) cause Graves' disease and contribute to Graves' Orbitopathy (GO) pathogenesis. We hypothesise that the presence of TSH binding proteins (truncated TSHR variants (TSHRv)) and/or nonclassical ligands such as thyrostimulin (α2β5) might provide a mechanism to protect against or exacerbate GO. We analysed primary human orbital preadipocyte-fibroblasts (OF) from GO patients and...

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Identifiers

PMID: 34889904
DOI: 10.3390/cimb43030126
PMCID: PMC8928972

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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