Article
Thiazolidinedione- and tumor necrosis factor alpha-induced downregulation of peroxisome proliferator-activated receptor gamma mRNA in differentiated 3T3-L1 adipocytes.
Metabolism: clinical and experimental - 1 Jan 2001
Perrey S, Ishibashi S, Yahagi N, Osuga J, Tozawa R, Yagyu H, Ohashi K, Gotoda T, Harada K, Chen Z, Iizuka Y, Shionoiri F, Yamada N
Abstract excerpt
Thiazolidinediones (TZDs) are antidiabetic insulin-sensitizing agents that bind to peroxisome proliferator-activated receptor gamma (PPARgamma) and have potent adipogenic effects on 3T3-L1 preadipocytes. In fully differentiated 3T3-L1 adipocytes, TZDs markedly decreased PPARgamma mRNA levels without reducing the expression of genes that are positively regulated by PPARgamma, such as adipocyte lipid-binding...
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