Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The CovR regulatory network drives the evolution of Group B Streptococcus virulence

7 Sept 2021

Abstract excerpt

Virulence of the neonatal pathogen Group B Streptococcus is under the control of the master regulator CovR. Inactivation of CovR is associated with large-scale transcriptome remodeling and impairs almost every step of the interaction between the pathogen and the host. However, transcriptome analyses suggested a plasticity of the CovR signaling pathway in clinical isolates leading to phenotypic heterogeneity in...

Topics

Join the communities discussing this publication.

Neonatal and Maternal Infections
Pneumonia and Respiratory Infections
Streptococcal Infections and Treatments

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 34491998
DOI: 10.1371/journal.pgen.1009761

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The CovR regulatory network drives the evolution of Group B Streptococcus virulencePMID 34491998Read ↗

The CovR regulatory network drives the evolution of Group B <i>Streptococcus</i> virulenceSemantic proximity Read ↗

CovS inactivation reduces CovR promoter binding at diverse virulence factor encoding genes in group A StreptococcusSemantic proximity Read ↗

CovS Simultaneously Activates and Inhibits the CovR-Mediated Repression of Distinct Subsets of Group A <i>Streptococcus</i> Virulence Factor-Encoding GenesSemantic proximity Read ↗

The two faces of Janus: virulence gene regulation by CovR/S in group A streptococciSemantic proximity Read ↗

Virulence control in group A Streptococcus by a two-component gene regulatory system: global expression profiling and in vivo infection modeling.Semantic proximity Read ↗

CovS/CovR of group B streptococcus: a two‐component global regulatory system involved in virulenceSemantic proximity Read ↗

Parallel Evolution of Group B Streptococcus Hypervirulent Clonal Complex 17 Unveils New Pathoadaptive MutationsSemantic proximity Read ↗

CovR-Controlled Global Regulation of Gene Expression in Streptococcus mutansSemantic proximity Read ↗

Signal-independent activation reveals two-component regulatory networksSemantic proximity Read ↗

A covR promoter mutation enhances Group B Streptococcus virulence by upregulating pgaC to reinforce capsular surface anchoring.Semantic proximity Read ↗

Characterization of the effect of the histidine kinase CovS on response regulator phosphorylation in group A Streptococcus.Semantic proximity Read ↗

Phosphatase activity of the control of virulence sensor kinase CovS is critical for the pathogenesis of group A streptococcusSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.