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Article

The CovR regulatory network drives the evolution of Group B Streptococcus virulence

7 Sept 2021

Abstract excerpt

Virulence of the neonatal pathogen Group B Streptococcus is under the control of the master regulator CovR. Inactivation of CovR is associated with large-scale transcriptome remodeling and impairs almost every step of the interaction between the pathogen and the host. However, transcriptome analyses suggested a plasticity of the CovR signaling pathway in clinical isolates leading to phenotypic heterogeneity in...

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PMID: 34491998
DOI: 10.1371/journal.pgen.1009761

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