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Article

Virulence control in group A Streptococcus by a two-component gene regulatory system: global expression profiling and in vivo infection modeling.

Proceedings of the National Academy of Sciences of the United States of America - 15 Oct 2002

Graham Morag R, Smoot Laura M, Migliaccio Cristi A Lux, Virtaneva Kimmo, Sturdevant Daniel E, Porcella Stephen F, Federle Michael J, Adams Gerald J, Scott June R, Musser James M

Abstract excerpt

Two-component gene regulatory systems composed of a membrane-bound sensor and cytoplasmic response regulator are important mechanisms used by bacteria to sense and respond to environmental stimuli. Group A Streptococcus, the causative agent of mild infections and life-threatening invasive diseases, produces many virulence factors that promote survival in humans. A two-component regulatory system, designated covRS...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 12370433
DOI: 10.1073/pnas.202353699
PMCID: PMC129787

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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