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Article

Functional and physical interactions between components of the Prp19p-associated complex.

Nucleic acids research - 15 Feb 2002

Chen Chun-Hong, Yu Wan-Chin, Tsao Twee Y, Wang Lian-Yung, Chen Hau-Ren, Lin Jui-Yen, Tsai Wei-Yü, Cheng Soo-Chen

Abstract excerpt

The Prp19p-associated complex is essential for the yeast pre-mRNA splicing reaction. The complex consists of at least eight protein components, but is not tightly associated with spliceosomal snRNAs. By a combination of genetic and biochemical methods we previously identified four components of this complex, Ntc25p, Ntc85p, Ntc30p and Ntc20p, all of them being novel splicing factors. We have now identified three...

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Identifiers

PMID: 11842115
DOI: 10.1093/nar/30.4.1029
PMCID: PMC100336

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

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Functional and physical interactions between components of the Prp19p-associated complex.PMID 11842115Read ↗

Identification and characterization of two novel components of the Prp19p-associated complex, Ntc30p and Ntc20p.Semantic proximity Read ↗

Snt309p, a component of the Prp19p-associated complex that interacts with Prp19p and associates with the spliceosome simultaneously with or immediately after dissociation of U4 in the same manner as Prp19p.Semantic proximity Read ↗

Structural and functional analysis of essential pre-mRNA splicing factor Prp19p.Semantic proximity Read ↗

Snt309p modulates interactions of Prp19p with its associated components to stabilize the Prp19p-associated complex essential for pre-mRNA splicing.Semantic proximity Read ↗

Four yeast spliceosomal proteins (PRP5, PRP9, PRP11, and PRP21) interact to promote U2 snRNP binding to pre-mRNA.Semantic proximity Read ↗

Interactions between PRP9 and SPP91 splicing factors identify a protein complex required in prespliceosome assembly.Semantic proximity Read ↗

The RNA binding protein Cwc2 interacts directly with the U6 snRNA to link the nineteen complex to the spliceosome during pre-mRNA splicing.Semantic proximity Read ↗

A targeted bypass screen identifies Ynl187p, Prp42p, Snu71p, and Cbp80p for stable U1 snRNP/Pre-mRNA interaction.Semantic proximity Read ↗

Activation of Prp28 ATPase by phosphorylated Npl3 at a critical step of spliceosome remodeling.Semantic proximity Read ↗

Mutations within the yeast U4/U6 snRNP protein Prp4 affect a late stage of spliceosome assembly.Semantic proximity Read ↗

The Prp19C subunits Cwc15 and Syf2 function in TREX occupancy and transcription elongationSemantic proximity Read ↗

Allele-specific genetic interactions between Prp8 and RNA active site residues suggest a function for Prp8 at the catalytic core of the spliceosome.Semantic proximity Read ↗

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