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Article

Activation-induced cytidine deaminase action is strongly stimulated by mutations of the THO complex.

Proceedings of the National Academy of Sciences of the United States of America - 15 May 2007

Gómez-González Belén, Aguilera Andrés

Abstract excerpt

Activation-induced cytidine deaminase (AID) is a B cell enzyme essential for Ig somatic hypermutation and class switch recombination. AID acts on ssDNA, and switch regions of Ig genes, a target of AID, form R-loops that contain ssDNA. Nevertheless, how AID action is specifically targeted to particular DNA sequences is not clear. Because mutations altering cotranscriptional messenger ribonucleoprotein (mRNP)...

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Identifiers

PMID: 17488823
DOI: 10.1073/pnas.0702836104
PMCID: PMC1895963

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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