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Article

AID induces double-strand breaks at immunoglobulin switch regions and c-MYC causing chromosomal translocations in yeast THO mutants.

PLoS genetics - 1 Feb 2011

Ruiz José F, Gómez-González Belén, Aguilera Andrés

Abstract excerpt

Transcription of the switch (S) regions of immunoglobulin genes in B cells generates stable R-loops that are targeted by Activation Induced Cytidine Deaminase (AID), triggering class switch recombination (CSR), as well as translocations with c-MYC responsible for Burkitt's lymphomas. In Saccharomyces cerevisiae, stable R-loops are formed co-transcriptionally in mutants of THO, a conserved nuclear complex involved...

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Share to Proto-Oncogene Proteins c-myc
Share to AICDA (Activation-Induced Cytidine Deaminase)

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Fungal

Share to Cytidine Deaminase

Share to DNA Breaks, Double-Stranded

Share to Immunoglobulin Switch Region

Share to Recombination, Genetic

Share to Translocation, Genetic

Source

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Identifiers

PMID: 21383964
DOI: 10.1371/journal.pgen.1002009
PMCID: PMC3044682

Genes

MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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AID induces double-strand breaks at immunoglobulin switch regions and c-MYC causing chromosomal translocations in yeast THO mutants.PMID 21383964Read ↗

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