Article
Asthma pharmacogenetic study using finite mixture models to handle drug-response heterogeneity.
Pharmacogenomics - 1 May 2009
York Timothy P, Vargas-Irwin Cristina, Anderson Wayne H, van den Oord Edwin J C G
Abstract excerpt
AIMS: Typically, only a proportion of the patients suffering from common diseases respond to frequently prescribed drugs. Since the presence of drug nonresponders in pharmacogenetic studies can adversely affect statistical power we propose a method to restrict genetic tests to drug responders only. In this paper, we estimate drug nonresponse in a clinical trial for the asthma drug montelukast as either the result...
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