Article
No evidence of large genetic effects on steroid response in asthma patients.
The Journal of allergy and clinical immunology - 1 Mar 2017
Mosteller Michael, Hosking Louise, Murphy Kay, Shen Judong, Song Kijoung, Nelson Matthew, Ghosh Soumitra
Abstract excerpt
BACKGROUND: Inhaled corticosteroids (ICSs) are considered the most effective anti-inflammatory therapy for asthma control and management; however, there is substantial treatment response variability. OBJECTIVE: We sought to identify genetic markers of ICS response by conducting the largest pharmacogenetic investigation to date in 2672 ICS-treated patients with asthma. METHODS: Genotyping and imputation was...
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