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Article

Rare genetic variants and treatment response: sample size and analysis issues.

Statistics in medicine - 10 Nov 2012

Witte John S

Abstract excerpt

Incorporating information about common genetic variants may help improve the design and analysis of clinical trials. For example, if genes impact response to treatment, one can pregenotype potential participants to screen out genetically determined nonresponders and substantially reduce the sample size and duration of a trial. Genetic associations with response to treatment are generally much larger than those...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22736504
DOI: 10.1002/sim.5428
PMCID: PMC3766744

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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