Article
Meta-analysis of genome-wide association data identifies two loci influencing age at menarche.
Nature genetics - 1 Jun 2009
Perry John R B, Stolk Lisette, Franceschini Nora, Lunetta Kathryn L, Zhai Guangju, McArdle Patrick F, Smith Albert V, Aspelund Thor, Bandinelli Stefania, Boerwinkle Eric, Cherkas Lynn, Eiriksdottir Gudny, Estrada Karol, Ferrucci Luigi, Folsom Aaron R, Garcia Melissa, Gudnason Vilmundur, Hofman Albert, Karasik David, Kiel Douglas P, Launer Lenore J, van Meurs Joyce, Nalls Michael A, Rivadeneira Fernando, Shuldiner Alan R, Singleton Andrew, Soranzo Nicole, Tanaka Toshiko, Visser Jenny A, Weedon Michael N, Wilson Scott G, Zhuang Vivian, Streeten Elizabeth A, Harris Tamara B, Murray Anna, Spector Tim D, Demerath Ellen W, Uitterlinden André G, Murabito Joanne M
Abstract excerpt
We conducted a meta-analysis of genome-wide association data to detect genes influencing age at menarche in 17,510 women. The strongest signal was at 9q31.2 (P = 1.7 × 10(-9)), where the nearest genes include TMEM38B, FKTN, FSD1L, TAL2 and ZNF462. The next best signal was near the LIN28B gene (rs7759938; P = 7.0 × 10(-9)), which also influences adult height. We provide the first evidence for common genetic...
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