Reproductive aging-associated common genetic variants and the risk of breast cancer.

doi:10.1186/bcr3155

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Reproductive aging-associated common genetic variants and the risk of breast cancer.

Breast cancer research : BCR - 20 Mar 2012

He Chunyan, Chasman Daniel I, Dreyfus Jill, Hwang Shih-Jen, Ruiter Rikje, Sanna Serena, Buring Julie E, Fernández-Rhodes Lindsay, Franceschini Nora, Hankinson Susan E, Hofman Albert, Lunetta Kathryn L, Palmieri Giuseppe, Porcu Eleonora, Rivadeneira Fernando, Rose Lynda M, Splansky Greta L, Stolk Lisette, Uitterlinden André G, Chanock Stephen J, Crisponi Laura, Demerath Ellen W, Murabito Joanne M, Ridker Paul M, Stricker Bruno H, Hunter David J

Abstract excerpt

INTRODUCTION: A younger age at menarche and an older age at menopause are well established risk factors for breast cancer. Recent genome-wide association studies have identified several novel genetic loci associated with these two traits. However, the association between these loci and breast cancer risk is unknown. METHODS: In this study, we investigated 19 and 17 newly identified single nucleotide polymorphisms...

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PMID: 22433456
DOI: 10.1186/bcr3155
PMCID: PMC3446388

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