Article
A large-scale candidate gene association study of age at menarche and age at natural menopause.
Human genetics - 1 Nov 2010
He Chunyan, Kraft Peter, Chasman Daniel I, Buring Julie E, Chen Constance, Hankinson Susan E, Paré Guillaume, Chanock Stephen, Ridker Paul M, Hunter David J
Abstract excerpt
Recent genome-wide association (GWA) studies have identified several novel genetic loci associated with age at menarche and age at natural menopause. However, the stringent significance threshold used in GWA studies potentially led to false negatives and true associations may have been overlooked. Incorporating biologically relevant information, we examined whether common genetic polymorphisms in candidate genes...
Topics
- Adolescent
- Age Factors
- Age of Onset
- Child
- Female
- Genetic Association Studies
- Genetic Predisposition to Disease
- Genotype
- Gonadal Steroid Hormones
- Humans
- Linear Models