Article
Compensatory evolution for a gene deletion is not limited to its immediate functional network.
BMC evolutionary biology - 16 May 2009
Harcombe W R, Springman R, Bull J J
Abstract excerpt
BACKGROUND: Genetic disruption of an important phenotype should favor compensatory mutations that restore the phenotype. If the genetic basis of the phenotype is modular, with a network of interacting genes whose functions are specific to that phenotype, compensatory mutations are expected among the genes of the affected network. This perspective was tested in the bacteriophage T3 using a genome deleted of its...
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