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Article

Pervasive compensatory adaptation in Escherichia coli.

Proceedings. Biological sciences - 7 Mar 2000

Moore F B, Rozen D E, Lenski R E

Abstract excerpt

To investigate compensatory adaptation (CA), we used genotypes of Escherichia coli which were identical except for one or two deleterious mutations. We compared CA for (i) deleterious mutations with large versus small effects, (ii) genotypes carrying one versus two mutations, and (iii) pairs of deleterious mutations which interact in a multiplicative versus synergistic fashion. In all, we studied 14 different...

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Identifiers

PMID: 10737410
DOI: 10.1098/rspb.2000.1030
PMCID: PMC1690552

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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