Article
Compensatory evolution in response to a novel RNA polymerase: orthologous replacement of a central network gene.
Molecular biology and evolution - 1 Apr 2007
Bull J J, Springman R, Molineux I J
Abstract excerpt
A bacteriophage genome was forced to evolve a new system of regulation by replacing its RNA polymerase (RNAP) gene, a central component of the phage developmental pathway, with that of a relative. The experiment used the obligate lytic phage T7 and the RNAP gene of phage T3. T7 RNAP uses 17 phage promoters, which are responsible for all middle and late gene expression, DNA replication, and progeny maturation, but...
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