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Article

Global genetic rewiring during compensatory evolution in the yeast polarity network.

EMBO reports - 1 Mar 2026

Kingma Enzo, Glazenburg Marieke, Olavarria Karel, Laan Liedewij

Abstract excerpt

Functional defects resulting from deleterious mutations can often be restored during evolution by compensatory mutations. Importantly, this process can generate the genetic diversity seen in networks regulating the same biological function in different species. How the options for compensatory evolution depend on the molecular interactions underlying these functions is currently unclear. We investigate how gene...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41699154
DOI: 10.1038/s44319-026-00709-4
PMCID: PMC13022240

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