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Article

Experimental genomic evolution: extensive compensation for loss of DNA ligase activity in a virus.

Molecular biology and evolution - 1 Mar 2002

Rokyta D, Badgett M R, Molineux I J, Bull J J

Abstract excerpt

Deletion of the viral ligase gene drastically reduced the fitness of bacteriophage T7 on a ligase-deficient host. Viral evolution recovered much of this fitness during long-term passage, but the final fitness remained below that of the intact virus. Compensatory changes occurred chiefly in genes involved in DNA metabolism: the viral endonuclease, helicase, and DNA polymerase. Two other compensatory changes of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11861882
DOI: 10.1093/oxfordjournals.molbev.a004076

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Experimental genomic evolution: extensive compensation for loss of DNA ligase activity in a virus.PMID 11861882Read ↗

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