Article
Site-specific analysis of UV-induced cyclobutane pyrimidine dimers in nucleotide excision repair-proficient and -deficient hamster cells: Lack of correlation with mutational spectra.
Mutation research - 26 Apr 2009
Vreeswijk Maaike P G, Meijers Caro M, Giphart-Gassler Micheline, Vrieling Harry, van Zeeland Albert A, Mullenders Leon H F, Loenen Wil A M
Abstract excerpt
Irradiation of cells with UVC light induces two types of mutagenic DNA photoproducts, i.e. cyclobutane pyrimidine dimers (CPD) and pyrimidine (6-4) pyrimidone photoproducts (6-4 PP). To investigate the relationship between the frequency of UV-induced photolesions at specific sites and their ability to induce mutations, we quantified CPD formation at the nucleotide level along exons 3 and 8 of the hprt gene using...
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