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Article

Nicotinic α5 receptor subunit mRNA expression is associated with distant 5' upstream polymorphisms.

European journal of human genetics : EJHG - 1 Jan 2011

Smith Ryan M, Alachkar Houda, Papp Audrey C, Wang Danxin, Mash Deborah C, Wang Jen-Chyong, Bierut Laura J, Sadee Wolfgang

Abstract excerpt

CHRNA5, encoding the nicotinic α5 subunit, is implicated in multiple disorders, including nicotine addiction and lung cancer. Previous studies demonstrate significant associations between promoter polymorphisms and CHRNA5 mRNA expression, but the responsible sequence variants remain uncertain. To...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20700147
DOI: 10.1038/ejhg.2010.120
PMCID: PMC2995013

Genes

CHRNA5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-20700147-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Nicotinic α5 receptor subunit mRNA expression is associated with distant 5' upstream polymorphisms.PMID 20700147Read ↗

The CHRNA5/CHRNA3/CHRNB4 Nicotinic Receptor Regulome: Genomic Architecture, Regulatory Variants, and Clinical Associations.Semantic proximity Read ↗

Cis-regulatory variants affect CHRNA5 mRNA expression in populations of African and European ancestry.Semantic proximity Read ↗

A multiancestry study identifies novel genetic associations with CHRNA5 methylation in human brain and risk of nicotine dependence.Semantic proximity Read ↗

Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5.Semantic proximity Read ↗

The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans.Semantic proximity Read ↗

Promoter polymorphisms and transcript levels of nicotinic receptor CHRNA5.Semantic proximity Read ↗

Rare, low frequency and common coding variants in CHRNA5 and their contribution to nicotine dependence in European and African Americans.Semantic proximity Read ↗

Functionally significant nicotine acetylcholine receptor subunit α5 promoter haplotypes are associated with susceptibility to lung cancer in Chinese.Semantic proximity Read ↗

In vitro and ex vivo analysis of CHRNA3 and CHRNA5 haplotype expression.Semantic proximity Read ↗

Rare nonsynonymous variants in alpha-4 nicotinic acetylcholine receptor gene protect against nicotine dependence.Semantic proximity Read ↗

Variants in nicotinic receptors and risk for nicotine dependence.Semantic proximity Read ↗

Multiple isoforms and differential allelic expression of CHRNA5 in lung tissue and lung adenocarcinoma.Semantic proximity Read ↗

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