Article
PLAUR polymorphisms are associated with asthma, PLAUR levels, and lung function decline.
The Journal of allergy and clinical immunology - 1 Jun 2009
Barton Sheila J, Koppelman Gerard H, Vonk Judith M, Browning Claudia A, Nolte Ilja M, Stewart Ceri E, Bainbridge Sue, Mutch Stacey, Rose-Zerilli Matthew J, Postma Dirkje S, Maniatis Nikolas, Henry Amanda P, Hall Ian P, Holgate Stephen T, Tighe Patrick, Holloway John W, Sayers Ian
Abstract excerpt
BACKGROUND: Several studies have suggested that chromosome 19q13.1-3 contains asthma susceptibility genes. OBJECTIVE: Linkage and association analyses using 587 United Kingdom and Dutch asthma families (n = 2819 subjects) were used to investigate this region. METHODS: A 3-phase procedure was used: (1) linkage and association analyses using 15 microsatellite markers spanning 14.4 mega base pairs (Mbps) on 19q13,...
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