Article
A genome-wide search for linkage to asthma phenotypes in the genetics of asthma international network families: evidence for a major susceptibility locus on chromosome 2p.
European journal of human genetics : EJHG - 1 Mar 2006
Pillai Sreekumar G, Chiano Mathias N, White Nicola J, Speer Marcy, Barnes Kathleen C, Carlsen Karin, Gerritsen Jorrit, Helms Peter, Lenney Warren, Silverman Michael, Sly Peter, Sundy John, Tsanakas John, von Berg Andrea, Whyte Moira, Varsani Shela, Skelding Paul, Hauser Michael, Vance Jeffery, Pericak-Vance Margaret, Burns Daniel K, Middleton Lefkos T, Brewster Shyama R, Anderson Wayne H, Riley John H
Abstract excerpt
Asthma is a complex disease and the intricate interplay between genetic and environmental factors underlies the overall phenotype of the disease. Families with at least two siblings with asthma were collected from Europe, Australia and the US. A genome scan using a set of 364 families with a panel of 396 microsatellite markers was conducted. Nonparametric linkage analyses were conducted for asthma and three...
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