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Article

Genome-wide protein QTL mapping identifies human plasma kallikrein as a post-translational regulator of serum uPAR levels.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Feb 2014

Portelli Michael A, Siedlinski Mateusz, Stewart Ceri E, Postma Dirkje S, Nieuwenhuis Maartje A, Vonk Judith M, Nurnberg Peter, Altmuller Janine, Moffatt Miriam F, Wardlaw Andrew J, Parker Stuart G, Connolly Martin J, Koppelman Gerard H, Sayers Ian

Abstract excerpt

The soluble cleaved urokinase plasminogen activator receptor (scuPAR) is a circulating protein detected in multiple diseases, including various cancers, cardiovascular disease, and kidney disease, where elevated levels of scuPAR have been associated with worsening prognosis and increased disease aggressiveness. We aimed to identify novel genetic and biomolecular mechanisms regulating scuPAR levels. Elevated serum...

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Identifiers

PMID: 24249636
DOI: 10.1096/fj.13-240879
PMCID: PMC3898658

Genes

KLKB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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