Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lack of association between tyrosine kinase 2 (TYK2) gene polymorphisms and susceptibility to SLE in a Japanese population.

Modern rheumatology - 1 Jan 2009

Kyogoku Chieko, Morinobu Akio, Nishimura Kunihiro, Sugiyama Daisuke, Hashimoto Hiroshi, Tokano Yoshiaki, Mimori Tsuneyo, Terao Chikashi, Matsuda Fumihiko, Kuno Takayoshi, Kumagai Shunichi

Abstract excerpt

Tyrosine kinase 2 (TYK2) is a type I interferon (IFN) signaling pathway gene and was previously reported to be a risk factor for systemic lupus erythematosus (SLE) in Caucasian populations. In order to test for its genetic association with SLE in a Japanese population, TYK2 single nucleotide polymorphisms (SNPs), rs2304256, rs12720270 and rs280519, were genotyped. A case-control association study was performed in...

Read the complete abstract on PubMed

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Case-Control Studies
Share to Genetic Predisposition to Disease
Share to Genotype
Share to Japan
Share to Linkage Disequilibrium
Share to Lupus Erythematosus, Systemic
Share to Polymorphism, Single Nucleotide
Share to TYK2 Kinase

Source

Identifiers

PMID: 19440814
DOI: 10.1007/s10165-009-0173-1

Genes

TYK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lack of association between tyrosine kinase 2 (TYK2) gene polymorphisms and susceptibility to SLE in a Japanese population.PMID 19440814Read ↗

Association between TYK2 polymorphisms and susceptibility to autoimmune rheumatic diseases: a meta-analysis.Semantic proximity Read ↗

Associations between PXK and TYK2 polymorphisms and systemic lupus erythematosus: a meta-analysis.Semantic proximity Read ↗

Genetic association and interaction between the IRF5 and TYK2 genes and systemic lupus erythematosus in the Han Chinese population.Semantic proximity Read ↗

Meta-analysis of TYK2 gene polymorphisms association with susceptibility to autoimmune and inflammatory diseases.Semantic proximity Read ↗

Evidence for genetic association and interaction between the TYK2 and IRF5 genes in systemic lupus erythematosus.Semantic proximity Read ↗

Association of polymorphisms across the tyrosine kinase gene, TYK2 in UK SLE families.Semantic proximity Read ↗

Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus.Semantic proximity Read ↗

The rs2304256 Polymorphism in TYK2 Gene Is Associated with Protection for Type 1 Diabetes Mellitus.Semantic proximity Read ↗

Lack of association between TYK2 and STAT3 genes and Crohn's disease in the Malaysian population.Semantic proximity Read ↗

Comprehensive analysis of three TYK2 gene variants in the susceptibility to Chagas disease infection and cardiomyopathy.Semantic proximity Read ↗

A rare variant of the TYK2 gene is confirmed to be associated with multiple sclerosis.Semantic proximity Read ↗

Tyrosine kinase 2 and interferon regulatory factor 5 polymorphisms are associated with discoid and subacute cutaneous lupus erythematosus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.