Article
NM23-H2 may play an indirect role in transcriptional activation of c-myc gene expression but does not cleave the nuclease hypersensitive element III(1).
Molecular cancer therapeutics - 1 May 2009
Dexheimer Thomas S, Carey Steven S, Zuohe Song, Gokhale Vijay M, Hu Xiaohui, Murata Lauren B, Maes Estelle M, Weichsel Andrzej, Sun Daekyu, Meuillet Emmanuelle J, Montfort William R, Hurley Laurence H
Abstract excerpt
The formation of G-quadruplex structures within the nuclease hypersensitive element (NHE) III(1) region of the c-myc promoter and the ability of these structures to repress c-myc transcription have been well established. However, just how these extremely stable DNA secondary structures are transformed to activate c-myc transcription is still unknown. NM23-H2/nucleoside diphosphate kinase B has been recognized as...
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