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Article

Induction of duplex to G-quadruplex transition in the c-myc promoter region by a small molecule.

The Journal of biological chemistry - 16 Feb 2001

Rangan A, Fedoroff O Y, Hurley L H

Abstract excerpt

A major control element of the human c-myc oncogene is the nuclease-hypersensitive purine/pyrimidine-rich sequence. This double-stranded DNA fragment, corresponding to the 27-base pair segment in the nuclease-hypersensitive element of the c-myc promoter region, forms a stable Watson-Crick double helix under physiological conditions. However, this duplex DNA can be effectively converted to G-quadruplex DNA by a...

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Source

Identifiers

PMID: 11035006
DOI: 10.1074/jbc.M005962200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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