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Article

Metastases suppressor NM23-H2 interaction with G-quadruplex DNA within c-MYC promoter nuclease hypersensitive element induces c-MYC expression.

Nucleic acids research - 1 Jan 2009

Thakur Ram Krishna, Kumar Praveen, Halder Kangkan, Verma Anjali, Kar Anirban, Parent Jean-Luc, Basundra Richa, Kumar Akinchan, Chowdhury Shantanu

Abstract excerpt

Regulatory influence of the G-quadruplex or G4 motif present within the nuclease hypersensitive element (NHE) in the promoter of c-MYC has been noted. On the other hand, association of NM23-H2 to the NHE leads to c-MYC activation. Therefore, NM23-H2 interaction with the G4 motif within the c-MYC...

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Topics

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Share to Binding Sites
Share to Deoxyribonucleases
Share to G-Quadruplexes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, myc

Share to NM23 Nucleoside Diphosphate Kinases

Share to Promoter Regions, Genetic

Share to Proto-Oncogene Proteins c-myc

Share to Transcriptional Activation

Source

Open in PubMed Open full text

Identifiers

PMID: 19033359
DOI: 10.1093/nar/gkn919
PMCID: PMC2615625

Genes

MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19033359-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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