Article
Mutations in the G-quadruplex silencer element and their relationship to c-MYC overexpression, NM23 repression, and therapeutic rescue.
Proceedings of the National Academy of Sciences of the United States of America - 20 Apr 2004
Grand Cory L, Powell Tiffanie J, Nagle Raymond B, Bearss David J, Tye Denise, Gleason-Guzman Mary, Hurley Laurence H
Abstract excerpt
We have demonstrated that a parallel G-quadruplex structure in the c-MYC promoter functions as a transcriptional repressor element. Furthermore, a specific G-to-A mutation in this element results in destabilization of the G-quadruplex repressor element and an increase in basal transcriptional activity. To validate this model in an in vivo context, we have examined the sequence of this region in human colorectal...
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