Article
Shh and Gli3 activities are required for timely generation of motor neuron progenitors.
Developmental biology - 15 Jul 2009
Oh SaeOck, Huang Xi, Liu Jiang, Litingtung Ying, Chiang Chin
Abstract excerpt
Generation of distinct ventral neuronal subtypes in the developing spinal cord requires Shh signaling mediated by the Gli family of transcription factors. Genetic studies of Shh(-/-);Gli3(-/-) double mutants indicated that the inhibition of Gli3 repressor activity by Shh is sufficient for the generation of different neurons including motor neurons. In this study, we show that although ventral neural progenitors...
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