All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3.

doi:10.1016/s1534-5807(03)00394-0

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Article

All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3.

Developmental cell - 1 Jan 2004

Bai C Brian, Stephen Daniel, Joyner Alexandra L

Abstract excerpt

An important question is how the gradient of Hedgehog is interpreted by cells at the level of the Gli transcription factors. The full range of Gli activity and its dependence on Hh have not been determined, although the Gli2 activator and Gli3 repressor have been implicated. Using the spinal cord as a model system, we demonstrate that Gli3 can transduce Hedgehog signaling as an activator. All expression of the Hh...

Topics

Animals
Body Patterning
Cell Differentiation
DNA-Binding Proteins
Fetus
Gene Expression Regulation, Developmental
Gene Targeting
Hedgehog Proteins
Interneurons
Kruppel-Like Transcription Factors
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Knockout

Motor Neurons

Mutation

Nerve Tissue Proteins

Oncogene Proteins

Signal Transduction

Spinal Cord

Source

Open in PubMed

Identifiers

PMID: 14723851
DOI: 10.1016/s1534-5807(03)00394-0

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