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Article

Differential requirement for Gli2 and Gli3 in ventral neural cell fate specification.

Developmental biology - 1 Jul 2003

Motoyama Jun, Milenkovic Ljiljana, Iwama Mizuho, Shikata Yayoi, Scott Matthew P, Hui Chi-chung

Abstract excerpt

Sonic hedgehog (Shh) directs the development of ventral cell fates, including floor plate and V3 interneurons, in the mouse neural tube. Here, we show that the transcription factors Gli2 and Gli3, mediators of Shh signaling, are required for the development of the ventral cell fates but make distinct contributions to controlling cell fates at different locations along the rostral-caudal axis. Mutants lacking...

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Identifiers

PMID: 12812795
DOI: 10.1016/s0012-1606(03)00159-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Differential requirement for Gli2 and Gli3 in ventral neural cell fate specification.PMID 12812795Read ↗

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