Differential requirement for Gli2 and Gli3 in ventral neural cell fate specification.

doi:10.1016/s0012-1606(03)00159-3

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Differential requirement for Gli2 and Gli3 in ventral neural cell fate specification.

Developmental biology - 1 Jul 2003

Motoyama Jun, Milenkovic Ljiljana, Iwama Mizuho, Shikata Yayoi, Scott Matthew P, Hui Chi-chung

Abstract excerpt

Sonic hedgehog (Shh) directs the development of ventral cell fates, including floor plate and V3 interneurons, in the mouse neural tube. Here, we show that the transcription factors Gli2 and Gli3, mediators of Shh signaling, are required for the development of the ventral cell fates but make distinct contributions to controlling cell fates at different locations along the rostral-caudal axis. Mutants lacking...

Topics

Animals
Body Patterning
DNA-Binding Proteins
Hedgehog Proteins
Interneurons
Kruppel-Like Transcription Factors
Membrane Proteins
Mice
Motor Neurons
Nerve Tissue Proteins
Patched Receptors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Patched-1 Receptor

Phenotype

Receptors, Cell Surface

Spinal Cord

Stem Cells

Trans-Activators

Transcription Factors

Source

Open in PubMed

Identifiers

PMID: 12812795
DOI: 10.1016/s0012-1606(03)00159-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Differential requirement for Gli2 and Gli3 in ventral neural cell fate specification.PMID 12812795Read ↗

Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation.Semantic proximity Read ↗

Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice.Semantic proximity Read ↗

Combinatorial Gli gene function in floor plate and neuronal inductions by Sonic hedgehog.Semantic proximity Read ↗

Patterning of ventral telencephalon requires positive function of Gli transcription factors.Semantic proximity Read ↗

Shh and Gli3 activities are required for timely generation of motor neuron progenitors.Semantic proximity Read ↗

The amino-terminal region of Gli3 antagonizes the Shh response and acts in dorsoventral fate specification in the developing spinal cord.Semantic proximity Read ↗

Differential susceptibility of midbrain and spinal cord patterning to floor plate defects in the talpid2 mutant.Semantic proximity Read ↗

Tubby-like protein 3 (TULP3) regulates patterning in the mouse embryo through inhibition of Hedgehog signaling.Semantic proximity Read ↗

Altered neural cell fates and medulloblastoma in mouse patched mutants.Semantic proximity Read ↗

Gli function is essential for motor neuron induction in zebrafish.Semantic proximity Read ↗

All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3.Semantic proximity Read ↗

Complementary Gli activity mediates early patterning of the mouse visual system.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.