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Article

E2F4 cooperates with pRB in the development of extra-embryonic tissues.

Developmental biology - 1 Aug 2009

Lee Eunice Y, Yuan Tina L, Danielian Paul S, West Julie C, Lees Jacqueline A

Abstract excerpt

The retinoblastoma gene, RB-1, was the first identified tumor suppressor. Rb(-/-) mice die in mid-gestation with defects in proliferation, differentiation and apoptosis. The activating E2F transcription factors, E2F1-3, contribute to these embryonic defects, indicating that they are key downstream targets of the retinoblastoma protein, pRB. E2F4 is the major pRB-associated E2F in vivo, yet its role in Rb(-/-)...

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Identifiers

PMID: 19433082
DOI: 10.1016/j.ydbio.2009.05.541
PMCID: PMC2832217

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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