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Article

E2F4 loss suppresses tumorigenesis in Rb mutant mice.

Cancer cell - 1 Dec 2002

Lee Eunice Y, Cam Hieu, Ziebold Ulrike, Rayman Joseph B, Lees Jacqueline A, Dynlacht Brian David

Abstract excerpt

The E2F transcription factors mediate the activation or repression of key cell cycle regulatory genes under the control of the retinoblastoma protein (pRB) tumor suppressor and its relatives, p107 and p130. Here we investigate how E2F4, the major "repressive" E2F, contributes to pRB's tumor-suppressive properties. Remarkably, E2F4 loss suppresses the development of both pituitary and thyroid tumors in Rb(+/-)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12498715
DOI: 10.1016/s1535-6108(02)00207-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Research trail→

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E2F4 loss suppresses tumorigenesis in Rb mutant mice.PMID 12498715Read ↗

Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1(+/-)mice.Semantic proximity Read ↗

Novel functions for the transcription factor E2F4 in development and diseaseSemantic proximity Read ↗

E2F3 loss has opposing effects on different pRB-deficient tumors, resulting in suppression of pituitary tumors but metastasis of medullary thyroid carcinomas.Semantic proximity Read ↗

Novel retinoblastoma mutation abrogating the interaction to E2F2/3, but not E2F1, led to selective suppression of thyroid tumors.Semantic proximity Read ↗

pRB binds to and modulates the transrepressing activity of the E1A-regulated transcription factor p120E4F.Semantic proximity Read ↗

Interchangeable Roles for E2F Transcriptional Repression by the Retinoblastoma Protein and p27KIP1-Cyclin-Dependent Kinase Regulation in Cell Cycle Control and Tumor Suppression.Semantic proximity Read ↗

Conserved RB functions in development and tumor suppressionSemantic proximity Read ↗

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E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle.Semantic proximity Read ↗

Visualizing dynamic E2F-mediated repression in vivo.Semantic proximity Read ↗

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