Article
An E2F binding-deficient Rb1 protein partially rescues developmental defects associated with Rb1 nullizygosity.
Molecular and cellular biology - 1 Feb 2006
Sun Huifang, Chang Yanjie, Schweers Brett, Dyer Michael A, Zhang Xiaojing, Hayward Simon W, Goodrich David W
Abstract excerpt
Rb1 is essential for normal embryonic development, as null mice die in midgestation with widespread unscheduled cell proliferation. Rb1 protein (pRb) mediates cell cycle control by binding E2F transcription factors and repressing expression from E2F-dependent promoters. An increasing amount of evidence suggests that pRb loss also compromises cellular differentiation. Since differentiation is often dependent on...
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