Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transcriptional regulator BPTF/FAC1 is essential for trophoblast differentiation during early mouse development.

Molecular and cellular biology - 1 Nov 2008

Goller Tobias, Vauti Franz, Ramasamy Suresh, Arnold Hans-Henning

Abstract excerpt

The putative transcriptional regulator BPTF/FAC1 is expressed in embryonic and extraembryonic tissues of the early mouse conceptus. The extraembryonic trophoblast lineage in mammals is essential to form the fetal part of the placenta and hence for the growth and viability of the embryo in utero. Here, we describe a loss-of-function allele of the BPTF/FAC1 gene that causes embryonic lethality in the mouse....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, Nuclear
Share to Brachyury Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytokines

Share to Embryo, Mammalian

Share to Fetal Proteins

Share to In Situ Hybridization

Share to T-Box Domain Proteins

Share to Trophoblasts

Source

Open in PubMed Open full text

Identifiers

PMID: 18794365
DOI: 10.1128/MCB.01058-08
PMCID: PMC2573307

Genes

BPTF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transcriptional regulator BPTF/FAC1 is essential for trophoblast differentiation during early mouse development.PMID 18794365Read ↗

Essential role of chromatin remodeling protein Bptf in early mouse embryos and embryonic stem cells.Semantic proximity Read ↗

Overlapping and unique roles for C-terminal binding protein 1 (CtBP1) and CtBP2 during mouse development.Semantic proximity Read ↗

<i>Cited1</i> Is Required in Trophoblasts for Placental Development and for Embryo Growth and SurvivalSemantic proximity Read ↗

An essential function of the mitogen-activated protein kinase Erk2 in mouse trophoblast development.Semantic proximity Read ↗

Transcriptional repressor erf determines extraembryonic ectoderm differentiation.Semantic proximity Read ↗

E2F4 cooperates with pRB in the development of extra-embryonic tissues.Semantic proximity Read ↗

Placentation defects are highly prevalent in embryonic lethal mouse mutants.Semantic proximity Read ↗

Murine FGFR-1 is required for early postimplantation growth and axial organization.Semantic proximity Read ↗

Transcription factor AP-2gamma is essential in the extra-embryonic lineages for early postimplantation development.Semantic proximity Read ↗

Birth defects associated with perturbations in preimplantation, gastrulation, and axis extension: from conjoined twinning to caudal dysgenesisSemantic proximity Read ↗

MCRS1 is essential for epiblast development during early mouse embryogenesis.Semantic proximity Read ↗

Winged helix transcription factor BF-1 is essential for the development of the cerebral hemispheres.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.