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Article

Rb is critical in a mammalian tissue stem cell population.

Genes & development - 1 Jan 2007

Wenzel Pamela L, Wu Lizhao, de Bruin Alain, Chong Jean-Leon, Chen Wen-Yi, Dureska Geoffrey, Sites Emily, Pan Tony, Sharma Ashish, Huang Kun, Ridgway Randall, Mosaliganti Kishore, Sharp Richard, Machiraju Raghu, Saltz Joel, Yamamoto Hideyuki, Cross James C, Robinson Michael L, Leone Gustavo

Abstract excerpt

The inactivation of the retinoblastoma (Rb) tumor suppressor gene in mice results in ectopic proliferation, apoptosis, and impaired differentiation in extraembryonic, neural, and erythroid lineages, culminating in fetal death by embryonic day 15.5 (E15.5). Here we show that the specific loss of R...

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Share to Embryo Loss
Share to Embryo, Mammalian

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Developmental

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Source

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Identifiers

PMID: 17210791
DOI: 10.1101/gad.1485307
PMCID: PMC1759903

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17210791-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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