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Article

Hyperglycemia-enhanced ischemic brain damage in mutant manganese SOD mice is associated with suppression of HIF-1alpha.

Neuroscience letters - 5 Jun 2009

Bullock Jeffery J, Mehta Suresh L, Lin Yanling, Lolla Padmavathi, Li P Andy

Abstract excerpt

Both preischemic hyperglycemia and reduction of manganese superoxide dismutase activity are known to enhance neuronal death induced by transient cerebral ischemia. Transcriptional factor hypoxia-inducible factor 1 (HIF-1) regulates multiple downstream genes that modulate cell metabolism, survival, death, angiogenesis, hematopoiesis, and other functions. The objectives of this study were to determine (i) whether...

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Identifiers

PMID: 19429140
DOI: 10.1016/j.neulet.2009.03.076
PMCID: PMC2680794

Genes

SOD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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