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Article

Pro-survival Phenotype of HIF-1α: Neuroprotection Through Inflammatory Mechanisms.

Advances in experimental medicine and biology - 1 Jan 2023

Puchowicz Michelle A, Parveen Kehkashan, Sethuraman Aarti, Ishrat Tauheed, Xu Kui, LaManna Joseph

Abstract excerpt

Hypoxia-inducible factor 1 (HIF-1) is a major player in the oxygen sensor system as well as a transcription factor. HIF-1 is also associated in the pathogenesis of many brain diseases including Alzheimer's disease (AD), epilepsy and stroke. HIF-1 regulates the expression of many genes such as those involved in glycolysis, erythropoiesis, angiogenesis and proliferation in hypoxic condition. Despite several...

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Identifiers

PMID: 37845436
DOI: 10.1007/978-3-031-42003-0_6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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