Deletion or Inhibition of the Oxygen Sensor PHD1 Protects against Ischemic Stroke via Reprogramming of Neuronal Metabolism.

doi:10.1016/j.cmet.2015.12.007

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Article

Deletion or Inhibition of the Oxygen Sensor PHD1 Protects against Ischemic Stroke via Reprogramming of Neuronal Metabolism.

Cell metabolism - 9 Feb 2016

Quaegebeur Annelies, Segura Inmaculada, Schmieder Roberta, Verdegem Dries, Decimo Ilaria, Bifari Francesco, Dresselaers Tom, Eelen Guy, Ghosh Debapriva, Davidson Shawn M, Schoors Sandra, Broekaert Dorien, Cruys Bert, Govaerts Kristof, De Legher Carla, Bouché Ann, Schoonjans Luc, Ramer Matt S, Hung Gene, Bossaert Goele, Cleveland Don W, Himmelreich Uwe, Voets Thomas, Lemmens Robin, Bennett C Frank, Robberecht Wim, De Bock Katrien, Dewerchin Mieke, Ghesquière Bart, Fendt Sarah-Maria, Carmeliet Peter

Abstract excerpt

The oxygen-sensing prolyl hydroxylase domain proteins (PHDs) regulate cellular metabolism, but their role in neuronal metabolism during stroke is unknown. Here we report that PHD1 deficiency provides neuroprotection in a murine model of permanent brain ischemia. This was not due to an increased collateral vessel network. Instead, PHD1(-/-) neurons were protected against oxygen-nutrient deprivation by...

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PMID: 26774962
DOI: 10.1016/j.cmet.2015.12.007
PMCID: PMC4880550

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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