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Article

Roles of individual prolyl-4-hydroxylase isoforms in the first 24 hours following transient focal cerebral ischaemia: insights from genetically modified mice.

The Journal of physiology - 15 Aug 2012

Chen Ruo-Li, Nagel Simon, Papadakis Michalis, Bishop Tammie, Pollard Patrick, Ratcliffe Peter J, Pugh Christopher W, Buchan Alastair M

Abstract excerpt

This study investigated the function of each of the hypoxia inducible factor (HIF) prolyl-4-hydroxylase enzymes (PHD1–3) in the first 24 h following transient focal cerebral ischaemia by using mice with each isoform genetically suppressed. Male, 8- to 12-week old PHD1−/−, PHD2+/− and PHD3−/− mice and their wild-type (WT) littermate were subjected to 45 min of middle cerebral artery occlusion (MCAO). During the...

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Identifiers

PMID: 22615432
DOI: 10.1113/jphysiol.2012.232884
PMCID: PMC3476649

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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